4 · Discussion
The proportion of 54.3% of patients being ruled-out is also satisfactory when considering rule-out rates between ∼48% and 65% in the literature for other hs-cTn assays using serial testing strategies. The achieved PPV of 58.5% and specificity of 92.2% using the prior derived cut-off values was relatively low compared to other studies. For the 0/1 h algorithm, PPVs between 63% and 75% for other hs-cTnT assays have been described.
- Who?
- Ben Völschow, Johannes T. Neumann and colleagues, University Heart and Vascular Center Hamburg, UKE
- What problem?
- Specificity of the Roche TnT hs Gen 6 assay: PPV 58.5% and specificity 92.2%, “relatively low compared to other studies”. Discussion, 2026.
- Why your solution?
- If your high-sensitivity cardiac assay is more specific in serial testing, this is the gap it addresses. Potential fit.
- Why reach out?
- They measured the shortfall themselves. Open with their numbers, not your brochure.
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